About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3706992
Allelic
Composition
Tlr4tm1Aki/Tlr4tm1Aki
Genetic
Background
B6.129P2-Tlr4tm1Aki
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr4tm1Aki mutation (5 available); any Tlr4 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice are resistant to lethal shock induced by a synthetic lipopeptide analogue (Myr3CSK4) (J:121930)
• mice are resistant to lethal shock induced by a synthetic lipopeptide analogue (Myr3CSK4) (J:121930)

respiratory system
N
• no significant increase in inflammatory cells in the lungs over time (J:114985)
• no significant increase in inflammatory cells in the lungs over time (J:114985)
• increased apoptosis in lungs (J:114985)
• increased apoptosis in lungs (J:114985)
• significantly increased lung volume at 3 months of age in contrast to normal body weights through 12 months (J:114985)
• significantly increased lung volume at 3 months of age in contrast to normal body weights through 12 months (J:114985)
• enlarged air spaces distal to the terminal bronchioles (J:114985)
• enlarged air spaces distal to the terminal bronchioles (J:114985)
• destruction of normal alveolar structures (J:114985)
• destruction of normal alveolar structures (J:114985)
• elastin fibers are thin and fragmented in the lung parenchyma (J:114985)
• reduced elastase inhibitory activity in serum and in bronchoalveolar lavage fluid (J:114985)
• elastin fibers are thin and fragmented in the lung parenchyma (J:114985)
• reduced elastase inhibitory activity in serum and in bronchoalveolar lavage fluid (J:114985)
• bronchoalveolar protein levels are increased by ozone exposure (J:147534)
• ozone induced increase in bronchoalveolar cell counts is less than in controls at 3 hours but not 24 hours (J:147534)
• bronchoalveolar protein levels are increased by ozone exposure (J:147534)
• ozone induced increase in bronchoalveolar cell counts is less than in controls at 3 hours but not 24 hours (J:147534)
• ozone exposure does not lead to hyperresponsiveness (J:147534)
• ozone exposure does not lead to hyperresponsiveness (J:147534)
• increased lung compliance (J:114985)
• increased lung compliance (J:114985)

homeostasis/metabolism
• azoxymethane and dextran sodium sulfate treatment to induce tumor formation (J:135620)
• no visible polyploid lesions are seen in the intestine as they are in controls (J:135620)
• only 5 of 18 mice have 1-2 small, flat dysplastic lesions compared to all controls having from 1 to 17 lesions, half of which are polyploid (J:135620)
• azoxymethane and dextran sodium sulfate treatment to induce tumor formation (J:135620)
• no visible polyploid lesions are seen in the intestine as they are in controls (J:135620)
• only 5 of 18 mice have 1-2 small, flat dysplastic lesions compared to all controls having from 1 to 17 lesions, half of which are polyploid (J:135620)
• reduced ischemia/reperfusion injury as indicated by a lower rise in serum urea and creatinine 1 day after injury (J:143920)
• reduced ischemia/reperfusion injury as indicated by a lower rise in serum urea and creatinine 1 day after injury (J:143920)

tumorigenesis
• azoxymethane and dextran sodium sulfate treatment to induce tumor formation (J:135620)
• no visible polyploid lesions are seen in the intestine as they are in controls (J:135620)
• only 5 of 18 mice have 1-2 small, flat dysplastic lesions compared to all controls having from 1 to 17 lesions, half of which are polyploid (J:135620)
• azoxymethane and dextran sodium sulfate treatment to induce tumor formation (J:135620)
• no visible polyploid lesions are seen in the intestine as they are in controls (J:135620)
• only 5 of 18 mice have 1-2 small, flat dysplastic lesions compared to all controls having from 1 to 17 lesions, half of which are polyploid (J:135620)

digestive/alimentary system
N
• level of colitis developed after azoxymethane and dextran sodium sulfate treatment is similar to controls (J:135620)
• level of colitis developed after azoxymethane and dextran sodium sulfate treatment is similar to controls (J:135620)

renal/urinary system
• reduced ischemia/reperfusion injury as indicated by a lower rise in serum urea and creatinine 1 day after injury (J:143920)
• reduced ischemia/reperfusion injury as indicated by a lower rise in serum urea and creatinine 1 day after injury (J:143920)
• fewer apoptotic tubular epithelial cells after ischemia/reperfusion injury as compared to controls except at 5 days after injury when apoptosis is elevated (J:143920)
• tubular epithelial cell proliferation is reduced 10 days after injury relative to controls (J:143920)
• fewer apoptotic tubular epithelial cells after ischemia/reperfusion injury as compared to controls except at 5 days after injury when apoptosis is elevated (J:143920)
• tubular epithelial cell proliferation is reduced 10 days after injury relative to controls (J:143920)
• less brush border loss after ischemia/reperfusion injury as compared to controls (J:143920)
• less brush border loss after ischemia/reperfusion injury as compared to controls (J:143920)
• reduced tubular necrosis after ischemia/reperfusion injury as compared to controls (J:143920)
• reduced tubular necrosis after ischemia/reperfusion injury as compared to controls (J:143920)
• less cast formation after ischemia/reperfusion injury as compared to controls (J:143920)
• less cast formation after ischemia/reperfusion injury as compared to controls (J:143920)

Mouse Models of Human Disease
OMIM ID Ref(s)
Emphysema, Hereditary Pulmonary 130700 J:114985


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/26/2016
MGI 6.02
The Jackson Laboratory