Phenotypes Associated with This Genotype

Genotype
MGI:3706991

• Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:139030 , J:210950 , J:4753 )

• increased susceptibility to L. monocytogenes-induced lethality with 100% lethality even when infected with a low titer of bacteria (J:139030)

• all mice infected with Listeria monocytogenes die unlike wild-type mice (J:210950)

• homozygotes succumb to infection following challenge with L. monocytogenes (J:4753)

• in contrast to wildtype, homozygotes exhibit very high titers of Listeria in spleen and liver by day 6 post-infection (J:4753)

decreased susceptibility to induced morbidity/mortality ( J:210950 )

• no mice treated with TNF die unlike wild-type mice

immune system

abnormal spleen germinal center morphology ( J:139030 )

• impaired formation of follicular dendritic cell networks and germinal centers following immunization with sheep red blood cells

decreased IgG level ( J:139030 )

• produce low titers of sheep red blood cell antibodies after immunization compared to wild-type controls

decreased circulating interleukin-6 level ( J:138824 )

• mice fail to produce IL-6 in response to I.V. injection of TNF while wild-type mice have dramatic increases in this cytokine 6 hours after injection

increased circulating tumor necrosis factor level ( J:139030 )

• in response to LPS stimulation, compared to controls

impaired humoral immune response ( J:210950 )

• mice immunized with sheep red blood cells fail to exhibit germinal centers and follicular dendritic cell networks with no antibody response unlike wild-type mice

decreased susceptibility to bacterial infection ( J:121930 , J:4753 )

• homozygotes are resistant to high dose (100 ug) bacterial LPS challenge and lethal doses of staphylococcal enterotoxin B (J:4753)

increased susceptibility to bacterial infection induced morbidity/mortality ( J:139030 , J:210950 , J:4753 )

• increased susceptibility to L. monocytogenes-induced lethality with 100% lethality even when infected with a low titer of bacteria (J:139030)

• all mice infected with Listeria monocytogenes die unlike wild-type mice (J:210950)

• homozygotes succumb to infection following challenge with L. monocytogenes (J:4753)

• in contrast to wildtype, homozygotes exhibit very high titers of Listeria in spleen and liver by day 6 post-infection (J:4753)

hematopoietic system

abnormal spleen germinal center morphology ( J:139030 )

• impaired formation of follicular dendritic cell networks and germinal centers following immunization with sheep red blood cells

decreased IgG level ( J:139030 )

• produce low titers of sheep red blood cell antibodies after immunization compared to wild-type controls

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:138824 )

• mice fail to produce IL-6 in response to I.V. injection of TNF while wild-type mice have dramatic increases in this cytokine 6 hours after injection

increased circulating tumor necrosis factor level ( J:139030 )

• in response to LPS stimulation, compared to controls

impaired skin barrier function ( J:59056 )

• slower recovery after superficial injury causes increased trans-epidermal water loss

abnormal response/metabolism to endogenous compounds ( J:210950 )

• TNF-treated mice fail to exhibit lethality, IL6 induction, hypothermia, sickness symptoms (ruffled fur, diarrhea and physical inactivity) or liver and kidney damage unlike wild-type mice

skeleton

increased bone mineral density ( J:135519 )

• significantly increased

integument

impaired skin barrier function ( J:59056 )

• slower recovery after superficial injury causes increased trans-epidermal water loss

cellular

increased sensitivity to induced cell death ( J:210950 )

• in mouse embryonic fibroblasts exposed to hypoxia