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Phenotypes Associated with This Genotype
Genotype
MGI:3706954
Allelic
Composition		 Npc1m1N/Npc1m1N
Tlr4tm1Aki/Tlr4tm1Aki
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npc1m1N mutation (3 available); any Npc1 mutation (72 available)
Tlr4tm1Aki mutation (7 available); any Tlr4 mutation (90 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal cytokine secretion ( J:118352 )
• fibroblasts isolated from 6-week old double null mice secrete ~30% of levels in Tlr-4-sufficient, Npc1-null fibroblasts

nervous system
nervous system phenotype ( J:118352 )
N
• number of activated glial cells in brains of double mutants is not different from Npc1-null brains

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory