Phenotypes Associated with This Genotype

Genotype
MGI:3706857

• Allelic Composition: Foxo1^tm1Rdp/Foxo1^tm1Rdp; Foxo3^tm1Rdp/Foxo3^tm1Rdp; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:118179 )

• development of hemangiomas leads to premature death starting at ~55 weeks of age with induced cre expression

neoplasm

increased tumor incidence ( J:118179 )

increased hemangioma incidence ( J:118179 )

• mice show widespread development of hemangiomas after cre induction; lesions are most exaggerated in uterus, visible at 6-8 weeks

increased hepatic hemangioma incidence ( J:118179 )

• discrete liver hemangiomas and occasionally angiosarcomas are observed in aged mice (7/10 that died at 50-82 weeks and 2/2 examined at 90-102 weeks)

increased hemangiosarcoma incidence ( J:118179 )

• in ~9% of mice, lesions progress to lethal angiosarcomas

cardiovascular system

abnormal blood vessel morphology ( J:118179 )

• all mice display mild vascular abnormalities with cre expression

liver/biliary system

increased hepatic hemangioma incidence ( J:118179 )

• discrete liver hemangiomas and occasionally angiosarcomas are observed in aged mice (7/10 that died at 50-82 weeks and 2/2 examined at 90-102 weeks)