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Phenotypes Associated with This Genotype
Genotype
MGI:3706857
Allelic
Composition
Foxo1tm1Rdp/Foxo1tm1Rdp
Foxo3tm1Rdp/Foxo3tm1Rdp
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1Rdp mutation (1 available); any Foxo1 mutation (7 available)
Foxo3tm1Rdp mutation (1 available); any Foxo3 mutation (11 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• discrete liver hemangiomas and occasionally angiosarcomas are observed in aged mice (7/10 that died at 50-82 weeks and 2/2 examined at 90-102 weeks)

mortality/aging
• development of hemangiomas leads to premature death starting at ~55 weeks of age with induced cre expression

neoplasm
• mice show widespread development of hemangiomas after cre induction; lesions are most exaggerated in uterus, visible at 6-8 weeks
• discrete liver hemangiomas and occasionally angiosarcomas are observed in aged mice (7/10 that died at 50-82 weeks and 2/2 examined at 90-102 weeks)
• in ~9% of mice, lesions progress to lethal angiosarcomas

cardiovascular system
• all mice display mild vascular abnormalities with cre expression


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory