Phenotypes Associated with This Genotype

Genotype
MGI:3706822

• Allelic Composition: Foxo1^tm1Rdp/Foxo1^tm1Rdp; Foxo3^tm1Rdp/Foxo3^tm1Rdp; Foxo4^tm1Rdp/Foxo4^tm1Rdp; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:118179 )

♀ • induced mice start to show significant mortality starting at ~22 weeks with ~90% mortality by 75 weeks of age

neoplasm

increased T cell derived lymphoma incidence ( J:118179 )

♀ • by 19-30 weeks, after cre induction, mice develop aggressive CD8+ CD4+ thymic lymphomas that spread to the spleen, lymph nodes and liver

♀ • wild-type mice and all other conditional genotypes examined here do not show any lymphomas up to 100 weeks of age

increased hamartoma incidence ( J:118179 )

♀ • mice develop an age-progressive hamarotomatous phenotype with cre expression

increased hemangioma incidence ( J:118179 )

♀ • mice show widespread development of hemangiomas, most exaggerated in uterus and visible by 6-8 weeks

♀ • lesions (usually benign) progress greatly by 30-40 weeks, with affected animals showing massive hemangiomas with intraluminal blood and thrombi in skeletal muscle, abdominal wall, liver, adrenal glands, bone marrow, omentum, lymph nodes, and skin

increased hemangiosarcoma incidence ( J:118179 )

♀ • in ~9% of mice, lesions progress to lethal angiosarcomas

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:118179 )

♀ • by 19-30 weeks, after cre induction, mice develop aggressive CD8+ CD4+ thymic lymphomas that spread to the spleen, lymph nodes and liver

♀ • wild-type mice and all other conditional genotypes examined here do not show any lymphomas up to 100 weeks of age