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Phenotypes Associated with This Genotype
Genotype
MGI:3706822
Allelic
Composition
Foxo1tm1Rdp/Foxo1tm1Rdp
Foxo3tm1Rdp/Foxo3tm1Rdp
Foxo4tm1Rdp/Foxo4tm1Rdp
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1Rdp mutation (1 available); any Foxo1 mutation (7 available)
Foxo3tm1Rdp mutation (1 available); any Foxo3 mutation (11 available)
Foxo4tm1Rdp mutation (1 available); any Foxo4 mutation (10 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• by 19-30 weeks, after cre induction, mice develop aggressive CD8+ CD4+ thymic lymphomas that spread to the spleen, lymph nodes and liver
• wild-type mice and all other conditional genotypes examined here do not show any lymphomas up to 100 weeks of age

mortality/aging
• induced mice start to show significant mortality starting at ~22 weeks with ~90% mortality by 75 weeks of age

neoplasm
• by 19-30 weeks, after cre induction, mice develop aggressive CD8+ CD4+ thymic lymphomas that spread to the spleen, lymph nodes and liver
• wild-type mice and all other conditional genotypes examined here do not show any lymphomas up to 100 weeks of age
• mice develop an age-progressive hamarotomatous phenotype with cre expression
• mice show widespread development of hemangiomas, most exaggerated in uterus and visible by 6-8 weeks
• lesions (usually benign) progress greatly by 30-40 weeks, with affected animals showing massive hemangiomas with intraluminal blood and thrombi in skeletal muscle, abdominal wall, liver, adrenal glands, bone marrow, omentum, lymph nodes, and skin
• in ~9% of mice, lesions progress to lethal angiosarcomas


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory