Phenotypes Associated with This Genotype

Genotype
MGI:3706818

• Allelic Composition: Foxo1^tm1Rdp/Foxo1^tm1Rdp; Foxo4^tm1Rdp/Foxo4^tm1Rdp; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:118179 )

♀ • development of hemangiomas leads to premature death starting to significant levels at ~50 weeks of age with induced cre expression

neoplasm

increased hamartoma incidence ( J:118179 )

♀ • mice develop an age-progressive hamarotomatous phenotype with cre expression

increased hemangioma incidence ( J:118179 )

♀ • females display mild hemangiomas, most exaggerated in the uterus and occasionally other tissues by 6-8 weeks after induction of cre expression with poly(I:C)

increased hepatic hemangioma incidence ( J:118179 )

♀ • discrete liver hemangiomas and occasionally angiosarcomas are observed in aged mice (5/7 in mice that died at 58-86 weeks and 2/2 examined at 96-98 weeks)

increased hemangiosarcoma incidence ( J:118179 )

♀ • in ~9% of mice, lesions progress to lethal angiosarcomas

liver/biliary system

increased hepatic hemangioma incidence ( J:118179 )

♀ • discrete liver hemangiomas and occasionally angiosarcomas are observed in aged mice (5/7 in mice that died at 58-86 weeks and 2/2 examined at 96-98 weeks)