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Phenotypes Associated with This Genotype
Genotype
MGI:3706818
Allelic
Composition
Foxo1tm1Rdp/Foxo1tm1Rdp
Foxo4tm1Rdp/Foxo4tm1Rdp
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1Rdp mutation (1 available); any Foxo1 mutation (7 available)
Foxo4tm1Rdp mutation (1 available); any Foxo4 mutation (10 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• discrete liver hemangiomas and occasionally angiosarcomas are observed in aged mice (5/7 in mice that died at 58-86 weeks and 2/2 examined at 96-98 weeks)

mortality/aging
• development of hemangiomas leads to premature death starting to significant levels at ~50 weeks of age with induced cre expression

neoplasm
• mice develop an age-progressive hamarotomatous phenotype with cre expression
• females display mild hemangiomas, most exaggerated in the uterus and occasionally other tissues by 6-8 weeks after induction of cre expression with poly(I:C)
• discrete liver hemangiomas and occasionally angiosarcomas are observed in aged mice (5/7 in mice that died at 58-86 weeks and 2/2 examined at 96-98 weeks)
• in ~9% of mice, lesions progress to lethal angiosarcomas


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory