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Phenotypes Associated with This Genotype
Genotype
MGI:3706814
Allelic
Composition
Foxo1tm1Rdp/Foxo1tm1Rdp
Tg(Mx1-cre)1Cgn/0
Genetic
Background
involves: 129S1/Sv * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1tm1Rdp mutation (1 available); any Foxo1 mutation (7 available)
Tg(Mx1-cre)1Cgn mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• development of hemangiomas leads to premature death becoming significant at ~55 weeks of age with induced cre expression

neoplasm
• when mice are treated with poly(I:C) to induce cre expression, 100% of females display mild hemangiomas in the uterus and perirenal fat by 60 weeks of age


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory