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Phenotypes Associated with This Genotype
Genotype
MGI:3706583
Allelic
Composition		 Ctnnb1tm2(Nfkbia)Rsu/Ctnnb1+
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 B6.Cg-Ctnnb1tm2(Nfkbia)Rsu Tg(Myh6-cre)2182Mds
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2(Nfkbia)Rsu mutation (0 available); any Ctnnb1 mutation (47 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased response of heart to induced stress ( J:111645 )
• mutants display an attenuated hypertrophic response compared with controls upon infusion of angiotensin II or isoproterenol as well as reduced expression of hypertrophy markers

homeostasis/metabolism
decreased response of heart to induced stress ( J:111645 )
• mutants display an attenuated hypertrophic response compared with controls upon infusion of angiotensin II or isoproterenol as well as reduced expression of hypertrophy markers

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory