Phenotypes Associated with This Genotype

Genotype
MGI:3706342

• Allelic Composition: Cyld^tm1Scs/Cyld^tm1Scs
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell differentiation ( J:112392 )

• B cell compartment in mutants is slighter larger than in wild-type

abnormal T cell number ( J:112392 )

• double positive cells are increased in proportion while single positive CD4 or CD8 cell proportion is decreased in mutants

increased double-positive T cell number ( J:112392 )

decreased CD4-positive, alpha-beta T cell number ( J:112392 )

• mice have fewer splenic CD4+ T cells than wild-type

decreased CD8-positive, alpha-beta T cell number ( J:112392 )

• mice have fewer splenic CD8+ T cells than wild-type

hematopoietic system

abnormal B cell differentiation ( J:112392 )

• B cell compartment in mutants is slighter larger than in wild-type

abnormal T cell number ( J:112392 )

• double positive cells are increased in proportion while single positive CD4 or CD8 cell proportion is decreased in mutants

increased double-positive T cell number ( J:112392 )

decreased CD4-positive, alpha-beta T cell number ( J:112392 )

• mice have fewer splenic CD4+ T cells than wild-type

decreased CD8-positive, alpha-beta T cell number ( J:112392 )

• mice have fewer splenic CD8+ T cells than wild-type

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:112392 )

• phosphorylation of Erk, Lat and Zap70 by Cyld is attenuated in purified double positive thymocytes