Phenotypes Associated with This Genotype

Genotype
MGI:3706123

• Allelic Composition: Rictor^tm1Mgn/Rictor^tm1Mgn
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:119564 )

• expected Mendelian distribution ratios by E11.5

• embryonic lethality was observed at later times, and only 1 live embryo was identified among 44 embryos at E16.5

homeostasis/metabolism

hydrops fetalis ( J:119564 )

• indistinguishable from either wild-type or heterozygous littermates prior to E12.5

• often displayed hydrops fetalis at later stages

• histologically normal and no major structural defects in any organ systems were found

embryo

abnormal placenta labyrinth morphology ( J:119564 )

• trophoblast giant cells number was increased and aberrantly distributed throughout the labyrinth layer in an E16.5 mutant mice

small placenta ( J:119564 )

• placenta was both smaller and thinner than wild-type littermate in an E16.5 mutant mice