Rictor^tm1Mgn
Targeted Allele Detail

Summary

• Symbol: Rictor^tm1Mgn
• Name: RPTOR independent companion of MTOR, complex 2; targeted mutation 1, Mark A Magnuson
• MGI ID: MGI:3526066
• Synonyms: ric^lacZ+neo, Rictor^fl
• Gene: Rictor Location: Chr15:6737860-6829882 bp, + strand Genetic Position: Chr15, 3.25 cM, cytoband A1
• Alliance: Rictor^tm1Mgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119564
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph, Reporter)
• Mutation: Insertion
• Mutation details: Two FRT sites flank a partial exon 3 which is linked to the lacZ reporter plus a floxed neomycin cassette. A third loxP site flanks intact exon 3 of the gene. QRT-PCR confirmed the absence of transcription. This allele is a hypomorph. (J:119564)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rictor Mutation: 140 strains or lines available

References

• Original: J:119564 Shiota C, et al., Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev Cell. 2006 Oct;11(4):583-9
• All: 18 reference(s)