Phenotypes for Smad2 Smad3 MGI:3703878 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Smad2^tm1.1Epb/Smad2^tm1.1Epb Smad3^tm1Cxd/Smad3^tm1Cxd
Genetic Background	involves: 129/Sv * 129S6/SvEvTac * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad2^tm1.1Epb mutation (1 available); any Smad2 mutation (50 available)
Smad3^tm1Cxd mutation (0 available); any Smad3 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:119642 )

• mice die between 1 and 8 months of age, due to primary defect in mucosal immune function

cellular

abnormal cell morphology ( J:119642 )

• after attachment to culture dishes, hepatocytes show relatively normal epithelial morphology but show wider cell-cell contacts and intracellular space compared to controls

decreased apoptosis ( J:119642 )

• after treatment with TGFbeta, cells show little or no apoptosis, compared to control or Smad2 conditional knockout cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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