About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3703798
Allelic
Composition
Tg(Tagln-rtTA)E1Jwst/0
Tg(tetO-BMPR2*T504)1Jwst/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tagln-rtTA)E1Jwst mutation (1 available)
Tg(tetO-BMPR2*T504)1Jwst mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• medial thickness of muscular pulmonary arteries is increased in DOX-treated mice at 8 weeks
• there is increased muscularization of small pulmonary arteries at the level of alveolar ducts
• right ventricle/left ventricle (RV/LV) + septum weight is increased 30% in DOX-treated mutants at 8 weeks
• right ventricle relative weight is increased compared to controls at 8 weeks
• transgenic mice receive doxycycline (DOX) in food up to 8 weeks of age, when assays are performed; at 8 weeks of age, DOX-treated mutants show 2-fold higher right ventricular systolic pressure
• DOX-treated mice show evidence of sustained pulmonary hypertension

muscle
• medial thickness of muscular pulmonary arteries is increased in DOX-treated mice at 8 weeks
• there is increased muscularization of small pulmonary arteries at the level of alveolar ducts

hematopoietic system
• modest increase in hematocrit in 8 week old DOX-treated mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Pulmonary Hypertension, Primary, 1; PPH1 178600 J:98898


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/19/2016
MGI 6.03
The Jackson Laboratory