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Transgene Detail
Symbol: Tg(tetO-BMPR2*T504)1Jwst
Name: transgene insertion 1, James West
MGI ID: MGI:3703793
Synonyms: tetO7-BMPRIIdelx+, TetO7-BMPRIIdelx4+
Transgene: Tg(tetO-BMPR2*T504)1Jwst  Location: unknown  
Alliance: Tg(tetO-BMPR2*T504)1Jwst page
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Dominant negative, Humanized sequence, Inducible, Inserted expressed sequence)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
Tg(tetO-BMPR2*T504)1Jwst expresses 1 gene
Mutation detailsSeven copies of the tetracycline responsive element and the CMV minimal promoter were used to drive the expression of a dominant-negative mutant BMPR2. The BMPR2 mutation is an insertion of a T at base 504 in the kinase (4th) domain of the protein, resulting in a premature stop 18 amino acids into the kinase domain. These transgenic mice were crossed to Tg(Tagln-rtTA)E1Jwst mice to obtain mice with inducible, muscle-specific expression of dominant-negative BMPR2. (J:98898)
View phenotypes and curated references for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:98898 West J, et al., Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle. Circ Res. 2004 Apr 30;94(8):1109-14
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
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