Phenotypes Associated with This Genotype

Genotype
MGI:3703591

• Allelic Composition: Fcer1a^tm1Knt/Fcer1a^tm1Knt
• Genetic Background: involves: 129 * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

reduced thrombolysis ( J:47138 )

• after stimulation with 2.4G2, the bone marrow mast cell degranulation response releases 35% of total cell granule content

immune system

abnormal mast cell physiology ( J:78659 )

• decreased mast cell degranulation relative to controls but extensive none the less

increased susceptibility to type I hypersensitivity reaction ( J:78659 )

• active anaphylaxis induced by OVA challenge in sensitized cells

• tachycardia is prolonged

• reduction in lung conductance is prolonged

• greater reduction of dynamic compliance in lungs

• IgG1 dependent passive systemic anaphylaxis occurs

hematopoietic system

abnormal mast cell physiology ( J:78659 )

• decreased mast cell degranulation relative to controls but extensive none the less