Phenotypes Associated with This Genotype

Genotype
MGI:3703441

• Allelic Composition: Fgfr1^tm2Jrt/Fgfr1^tm2Jrt; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

craniofacial phenotype ( J:81179 )

N • the palate is closed, unlike in mice homozygous for Fgfr1^tm2Jrt alone

abnormal alisphenoid bone morphology ( J:81179 )

• posterior part are always affected

abnormal pterygoid bone morphology ( J:81179 )

• flattened

abnormal temporal bone squamous part morphology ( J:81179 )

• posterior part are always affected

abnormal middle ear ossicle morphology ( J:81179 )

abnormal incus morphology ( J:81179 )

• variable deficiencies

abnormal malleus morphology ( J:81179 )

• variable deficiencies

small gonial bone ( J:81179 )

• reduced gonial bone

abnormal second pharyngeal arch morphology ( J:81179 )

• disruption in second branchial arch development is similar to that in Fgfr1^tm2Jrt homozygotes

hearing/vestibular/ear

abnormal middle ear ossicle morphology ( J:81179 )

abnormal incus morphology ( J:81179 )

• variable deficiencies

abnormal malleus morphology ( J:81179 )

• variable deficiencies

small gonial bone ( J:81179 )

• reduced gonial bone

decreased tympanic ring size ( J:81179 )

• reduced

skeleton

abnormal alisphenoid bone morphology ( J:81179 )

• posterior part are always affected

abnormal pterygoid bone morphology ( J:81179 )

• flattened

abnormal temporal bone squamous part morphology ( J:81179 )

• posterior part are always affected

abnormal middle ear ossicle morphology ( J:81179 )

abnormal incus morphology ( J:81179 )

• variable deficiencies

abnormal malleus morphology ( J:81179 )

• variable deficiencies

small gonial bone ( J:81179 )

• reduced gonial bone

embryo

abnormal second pharyngeal arch morphology ( J:81179 )

• disruption in second branchial arch development is similar to that in Fgfr1^tm2Jrt homozygotes