Phenotypes Associated with This Genotype

Genotype
MGI:3703438

• Allelic Composition: Alox15^tm1Fun/Alox15^tm1Fun
• Genetic Background: B6.129S2-Alox15^tm1Fun/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased spleen weight ( J:119405 )

• progressive splenomegaly is observed after 8 weeks of age

mortality/aging

premature death ( J:119405 )

• increase in death rate of homozygous mice as compared to controls

• 80% survival at 12 months of age

• severe anemia is most likely cause of death

hematopoietic system

increased spleen weight ( J:119405 )

• progressive splenomegaly is observed after 8 weeks of age

abnormal myelopoiesis ( J:119405 )

• increase in numbers of myeloid cells in bone marrow, spleen, blood and lymph nodes as compared to control

• cell cycle analysis indicates an increase in proliferative capacity of splenic myeloid cells and a decrease in the percentage of apoptotic cells

anemia ( J:119405 )

• presumed cause of premature death

abnormal bone marrow cell number ( J:119405 )

• increase in number of myeloid cells and progenitors, as well as megkaryocytes

abnormal myeloblast morphology/development ( J:119405 )

• at death, cells in bone marrow of homozygous mice consist of greater than 25% myeloblasts

increased leukocyte cell number ( J:119405 )

• blood leukocystosis observed in asymptomatic and moribund mice

increased basophil cell number ( J:119405 )

• basophilia observed in asymptomatic and moribund mice

abnormal spleen red pulp morphology ( J:119405 )

• disrupted compartmentalization of red pulp

abnormal spleen white pulp morphology ( J:119405 )

• disrupted compartmentalization of white pulp

intermingled spleen red and white pulp ( J:119405 )

• moribund mice exhibit complete loss of splenic compartmentalization

decreased spleen B cell follicle number ( J:119405 )

• decrease in number of follicles

immune system

increased spleen weight ( J:119405 )

• progressive splenomegaly is observed after 8 weeks of age

abnormal myelopoiesis ( J:119405 )

• increase in numbers of myeloid cells in bone marrow, spleen, blood and lymph nodes as compared to control

• cell cycle analysis indicates an increase in proliferative capacity of splenic myeloid cells and a decrease in the percentage of apoptotic cells

increased leukocyte cell number ( J:119405 )

• blood leukocystosis observed in asymptomatic and moribund mice

increased basophil cell number ( J:119405 )

• basophilia observed in asymptomatic and moribund mice

abnormal spleen red pulp morphology ( J:119405 )

• disrupted compartmentalization of red pulp

abnormal spleen white pulp morphology ( J:119405 )

• disrupted compartmentalization of white pulp

intermingled spleen red and white pulp ( J:119405 )

• moribund mice exhibit complete loss of splenic compartmentalization

decreased spleen B cell follicle number ( J:119405 )

• decrease in number of follicles

abnormal lymph node morphology ( J:119405 )

• although not enlarged, lymph nodes exhibit progressive hypercellularity

• pseudo-Gaucher cells observed in lymph nodes

• increase in GR-1+ myeloid cells as compared to controls

dermatitis ( J:119405 )

• myeloid infiltrates observed in skin of moribund mice

neoplasm

increased chronic myelocytic leukemia incidence ( J:119405 )

• mice older than 10 weeks develop a malignant myeloproliferative disease at 100% penetrance that can progress to transplantable leukemia

integument

dermatitis ( J:119405 )

• myeloid infiltrates observed in skin of moribund mice