Mouse Genome Informatics
ht
    Psen1tm1Mpm/Psen1tm1Pcw
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• exhibit impaired hippocampus-dependent contextual fear learning at 3 months of age, showing reduced freezing behavior
• however, show normal cued fear learning, anxiety, motor coordination and shock threshold

nervous system
• exhibit a 35% decrease in the number of newborn cells in the dentate gyrus of 3-month old mutants, indicating impaired adult neurogenesis

cellular
• exhibit a 35% decrease in the number of newborn cells in the dentate gyrus of 3-month old mutants, indicating impaired adult neurogenesis

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease 3 607822 J:91277
Alzheimer Disease; AD 104300 J:91277