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Phenotypes Associated with This Genotype
Genotype
MGI:3702925
Allelic
Composition
Psen1tm1Mpm/Psen1tm1Pcw
Genetic
Background
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Mpm mutation (2 available); any Psen1 mutation (35 available)
Psen1tm1Pcw mutation (0 available); any Psen1 mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• exhibit impaired hippocampus-dependent contextual fear learning at 3 months of age, showing reduced freezing behavior
• however, show normal cued fear learning, anxiety, motor coordination and shock threshold

nervous system
• exhibit a 35% decrease in the number of newborn cells in the dentate gyrus of 3-month old mutants, indicating impaired adult neurogenesis

cellular
• exhibit a 35% decrease in the number of newborn cells in the dentate gyrus of 3-month old mutants, indicating impaired adult neurogenesis


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory