Phenotypes Associated with This Genotype

Genotype
MGI:3702915

• Allelic Composition: Ighm^tm1Cgn/Ighm^tm1Cgn
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:112160 )

• CD4⁺ T cells isolated from antigen-challenged mice have reduced proliferation in response to antigen encounter in vitro

arrested B cell differentiation ( J:118453 )

• B cell development is halted at pre-B cell stage, indicated by lack of CD25+ B-cells

absent mature B cells ( J:118453 )

• in bone marrow and spleen, mature (B220+) B lymphocytes are lacking

increased osteoclast cell number ( J:157619 )

abnormal metallophilic macrophage morphology ( J:88620 )

• marginal metallophilic macrophages are absent

abnormal spleen marginal zone macrophage morphology ( J:88620 )

• MARCO+ cells are absent

abnormal spleen marginal sinus morphology ( J:88620 )

• sinus lining cells (MAdCAM-1+) are absent

decreased IgA level ( J:157450 )

• absent

decreased IgG level ( J:157450 )

• absent

abnormal CD4-positive, alpha-beta T cell physiology ( J:112160 )

• CD4⁺ T cells isolated from antigen-challenged mice have reduced proliferation in response to antigen encounter in vitro

absent follicular dendritic cells ( J:88620 )

• follicular dendritic cells are absent

decreased susceptibility to type IV hypersensitivity reaction ( J:112160 )

• footpad swelling of antigen-sensitized mice is less than controls

abnormal antigen presentation ( J:112160 )

• CD4⁺ T cells have normal primary responses suggesting lower T cell activity from immunized mice is a failure in antigen presentation

increased susceptibility to induced arthritis ( J:157619 )

increased susceptibility to parasitic infection ( J:163761 )

• after second infestation to ticks, mice fail to exhibit resistance (repletion) unlike similarly treated wild-type mice

hematopoietic system

decreased T cell proliferation ( J:112160 )

• CD4⁺ T cells isolated from antigen-challenged mice have reduced proliferation in response to antigen encounter in vitro

arrested B cell differentiation ( J:118453 )

• B cell development is halted at pre-B cell stage, indicated by lack of CD25+ B-cells

absent mature B cells ( J:118453 )

• in bone marrow and spleen, mature (B220+) B lymphocytes are lacking

increased osteoclast cell number ( J:157619 )

abnormal metallophilic macrophage morphology ( J:88620 )

• marginal metallophilic macrophages are absent

abnormal spleen marginal zone macrophage morphology ( J:88620 )

• MARCO+ cells are absent

abnormal spleen marginal sinus morphology ( J:88620 )

• sinus lining cells (MAdCAM-1+) are absent

decreased IgA level ( J:157450 )

• absent

decreased IgG level ( J:157450 )

• absent

abnormal CD4-positive, alpha-beta T cell physiology ( J:112160 )

• CD4⁺ T cells isolated from antigen-challenged mice have reduced proliferation in response to antigen encounter in vitro

skeleton

increased osteoclast cell number ( J:157619 )

increased susceptibility to induced arthritis ( J:157619 )

cellular

decreased T cell proliferation ( J:112160 )

• CD4⁺ T cells isolated from antigen-challenged mice have reduced proliferation in response to antigen encounter in vitro