Phenotypes for Gnl3 Trp53 MGI:3702081 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gnl3^{Gt(W223E05)Wrst}/Gnl3^{Gt(W223E05)Wrst} Trp53^tm1Tyj/Trp53^tm5Tyj
Genetic Background	involves: 129S2/SvPas * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnl3^{Gt(W223E05)Wrst} mutation (0 available); any Gnl3 mutation (58 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
Trp53^tm5Tyj mutation (1 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:118144 )

• loss of Trp53 expression does not alter or delay the lethality

embryo

embryonic growth arrest ( J:118144 )

• loss of Trp53 expression does not alter or delay the overall phenotype

cellular

decreased cell proliferation ( J:118144 )

• loss of Trp53 expression does not alter or delay the impairment of cell proliferation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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