Phenotypes Associated with This Genotype

Genotype
MGI:3701780

• Allelic Composition: Del(16Zfp520-Slc25a1)1Awb/+
• Genetic Background: involves: 129S6/SvEvTac * NIH Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:58432 )

• no homozygous mutants are born; between E5.5 and E7.5, normal-appearing embryos and empty deciduae are found, suggesting early post-implantation homozygous lethality

embryo

inner cell mass degeneration ( J:58432 )

• inner cell mass cells of homozygous blastocysts often do not hatch after 4 days and degenerate soon afterwards

nervous system

abnormal prepulse inhibition ( J:58432 )

• prepulse inhibition response is abnormal in heterozygous mice; percent inhibition is significantly higher than in controls

• Background Sensitivity: levels of prepulse inhibition are lower at the 2 highest prepulse sound levels than on inbred 129S6/SvEvTac background

behavior/neurological

behavior/neurological phenotype ( J:58432 )

N • open field behaviors, acoustic startle responses, contextual and cued fear responses are similar in mutants and wild-type

impaired coordination ( J:58432 )

• male mice perform more poorly compared than wild-type mice in the rotarod test

cardiovascular system

cardiovascular system phenotype ( J:58432 )

N • mutants do not show abnormal development of cardiovascular system and do not show signs of DiGeorge Syndrome or VCS