Phenotypes Associated with This Genotype

Genotype
MGI:3700235

• Allelic Composition: Mdm4^{Gt(VICTR20)7Lex}/Mdm4^{Gt(VICTR20)7Lex}; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:77907 )

N • double homozygotes are viable, unlike mice homozygous for the Mdm4 allele alone

embryo

embryo phenotype ( J:77907 )

N • appear indistinguishable from control littermates at E10.5, unlike mice homozygous for the Mdm4 mutation alone

cellular

abnormal cell cycle checkpoint function ( J:77907 )

• gamma-irradiation fails to produce an increase in the relative number of cells in G1 compared to S phase similar to what is seen in MEFs homozygous for the Trp53 allele alone

decreased cellular sensitivity to ultraviolet irradiation induced cell death ( J:77907 )

• reduced sensitivity to UV-induced cell death in MEFs similar to cells homozygous for Trp53 alone

increased fibroblast proliferation ( J:77907 )

• similar to MEFs homozygous for the Trp53 allele alone, proliferation is increased relative to control cells