Phenotypes Associated with This Genotype

Genotype
MGI:3700173

• Allelic Composition: Terf2^tm1Tdl/Terf2^tm1.1Tdl; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal chromosome morphology ( J:112957 )

• following pI-pC injection to induce cre expression, telomeres undergo end-to-end fusions in quiescent hepatocytes, indicating telomere deprotection, however, hepatocytes are resistant to this damage and are functional in the presence of chromosome end fusions as indicated by normal liver function

• the telomere fusions seen in mutants do not impair liver regeneration after partial hepatectomy as regeneration occurs without cell division involving endoreduplication and cell growth, circumventing the chromosome segregation problems associated with telomere fusions

liver/biliary system

abnormal hepatocyte morphology ( J:112957 )

• following pI-pC injection to induce cre expression, telomeres undergo end-to-end fusions in quiescent hepatocytes, indicating telomere deprotection, however, hepatocytes are resistant to this damage and are functional in the presence of chromosome end fusions as indicated by normal liver function