Analysis Tools
homeostasis/metabolism
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• platelet thrombus formation is severely impaired ex vivo after treatment of platelets with polyinosinic-polycytidylic acid (PIPC) to induce recombination
• however, initial adhesion of platelets is similar to wild-type
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• serotonin secretion induced by U46619 plus adrenaline or Par-4 peptide exposure is significantly decreased compared to wild-type cells
• however, thrombin-induced serotonin secretion is not impaired
• absence of a shape change in response to low concentration of stimuli compared to wild-type following polyinosinic-polycytidylic acid (PIPC) treatment
• however, shape change is induced with high concentration of stimuli
• potency of agonists to induce aggregation is reduced but aggregation occurs at all agonist concentrations
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• potency of agonists to induce aggregation is reduced but aggregation occurs at all agonist concentrations
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• very large increase in bleeding time in interferon-responsive tissues
• when bone marrow-derived cells PIPC-treated mice are transplanted into irradiated wild-type mice, 4 weeks later mice have greatly prolonged bleeding times (>20 minutes) compared with mice receiving cells from noninduced controls
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hematopoietic system
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• serotonin secretion induced by U46619 plus adrenaline or Par-4 peptide exposure is significantly decreased compared to wild-type cells
• however, thrombin-induced serotonin secretion is not impaired
• absence of a shape change in response to low concentration of stimuli compared to wild-type following polyinosinic-polycytidylic acid (PIPC) treatment
• however, shape change is induced with high concentration of stimuli
• potency of agonists to induce aggregation is reduced but aggregation occurs at all agonist concentrations
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• potency of agonists to induce aggregation is reduced but aggregation occurs at all agonist concentrations
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