Phenotypes Associated with This Genotype

Genotype
MGI:3699334

• Allelic Composition: Gnas^tm3Lsw/Gnas^tm3Lsw; Ren1^tm2(cre)Gom/Ren1⁺
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating aldosterone level ( J:118076 )

decreased circulating renin level ( J:118076 )

• exhibit reduced basal levels of renin expression and very low plasma renin concentrations

decreased urine osmolality ( J:118076 )

• urine osmolarity is only slightly above isotonicity and significantly lower than in controls

increased urine prostaglandin level ( J:118076 )

• excretion of PGE2 in urine is significantly higher

abnormal renin activity ( J:118076 )

• acute stimulation of renin release in response to furosemide, hydralazine, and isoproterenol are abolished

renal/urinary system

decreased urine osmolality ( J:118076 )

• urine osmolarity is only slightly above isotonicity and significantly lower than in controls

increased urine prostaglandin level ( J:118076 )

• excretion of PGE2 in urine is significantly higher

abnormal kidney physiology ( J:118076 )

• renin release by juxtaglomerular cells is significantly lower

decreased renal glomerular filtration rate ( J:118076 )

cardiovascular system

decreased mean systemic arterial blood pressure ( J:118076 )

• reduction in mean arterial blood pressure both at night and during the day