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Phenotypes Associated with This Genotype
Genotype
MGI:3699320
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Gna12tm1Citb/Gna12tm1Citb
Gna13tm2.1Soff/Gna13tm2.1Soff
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Gna12tm1Citb mutation (0 available); any Gna12 mutation (23 available)
Gna13tm2.1Soff mutation (0 available); any Gna13 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased marginal zone B cell number ( J:117663 )
• marginal zone B cell numbers are strongly reduced compared to controls
abnormal B cell physiology ( J:117663 )
• lysophospholipid-induced induced adhesion is completely abrogated in marginal zone mutant B cells and is reduced in follicular B cells
• lysophospholipid-induced induced LFA-1 (integrin) clustering is abolished in mutant B cells

immune system
decreased marginal zone B cell number ( J:117663 )
• marginal zone B cell numbers are strongly reduced compared to controls
abnormal B cell physiology ( J:117663 )
• lysophospholipid-induced induced adhesion is completely abrogated in marginal zone mutant B cells and is reduced in follicular B cells
• lysophospholipid-induced induced LFA-1 (integrin) clustering is abolished in mutant B cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory