Analysis Tools
hearing/vestibular/ear
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• prolonged latency for all peaks and larger amplitudes for P1/N1
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nervous system
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• onset of seizures begins at 6-8 weeks of age; seizures occur less frequently than in homozygous Qke5 mice
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• aging mutants exhibit Purkinje cell axonal swellings, indicating neurodegeneration
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• decrease in myelination, however more axons are surrounded by thin myelin sheaths than seen in Qke5 homozygotes
(J:102038)
• microsomes prepared from brains of 18 day old homozygotes show a reduction in fatty acid chain elongation activity with arachidoyl CoA, behenoyl CoA, and palmitoyl CoA substrates
(J:160743)
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behavior/neurological
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• onset of seizures begins at 6-8 weeks of age; seizures occur less frequently than in homozygous Qke5 mice
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reproductive system
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• the testis contain many spermatogenic cells, but few spermatozoa and the spermatozoa collected from the cauda epididymis all have abnormal heads and/or tails and less than 0.5% are barely motile, and although in vitro fertilization is not successful, intracytoplasmic sperm injection and round spermatid injection are successful in production of offspring from homozygous males
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necrospermia
(
J:88151
)
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cellular
necrospermia
(
J:88151
)
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