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Phenotypes Associated with This Genotype
Genotype
MGI:3698742
Allelic
Composition		 Zap70m1Saka/Zap70m1Saka
Tg(DO11.10)10Dlo/0
Genetic
Background		 involves: BALB/c * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(DO11.10)10Dlo mutation (7 available)
Zap70m1Saka mutation (1 available); any Zap70 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell proliferation ( J:86607 )
• T cells require a 10-fold greater concentration of ovalbumin peptide to proliferate to the same extent and wild-type Tg(DO11.10)10Dlo T cells
decreased T cell number ( J:86607 )
• number of CD4+CD8- mature thymocytes decreases to ~20% that in control Tg(DO11.10)10Dlo mice

hematopoietic system
decreased T cell proliferation ( J:86607 )
• T cells require a 10-fold greater concentration of ovalbumin peptide to proliferate to the same extent and wild-type Tg(DO11.10)10Dlo T cells
decreased T cell number ( J:86607 )
• number of CD4+CD8- mature thymocytes decreases to ~20% that in control Tg(DO11.10)10Dlo mice

cellular
decreased T cell proliferation ( J:86607 )
• T cells require a 10-fold greater concentration of ovalbumin peptide to proliferate to the same extent and wild-type Tg(DO11.10)10Dlo T cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory