Phenotypes Associated with This Genotype

Genotype
MGI:3698738

• Allelic Composition: Hr^hr/Hr^hr
• Genetic Background: HRS/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Hr^hr/Hr^hr mouse

hearing/vestibular/ear

absent linear vestibular evoked potential ( J:116914 )

• VESPs are absent at the maximum stimulus intensity used

neoplasm

increased leukemia incidence ( J:5726 , J:5908 , J:24786 )

• increased incidence (J:5726)

• increased incidence (J:5908)

• at 8 to 10 months of age 45% of homozygotes have lymphoid leukemia, compared with only 1% in heterozygotes, and approximately 72% of these homozygotes develop myeloid leukemia later in life up to 18 months of age (J:24786)

hematopoietic system

decreased T cell proliferation ( J:6375 )

• to alloantigens by T helper cells

decreased T cell number ( J:6087 )

• of CD5+ T cells

increased macrophage cell number ( J:150402 )

• although heterozygotes and homozygotes have the same total number of peritoneal cells, the percentage expressing Mac-1 is an average of 30% in homozygotes versus an average of 14% in heterozygotes

immune system

decreased T cell proliferation ( J:6375 )

• to alloantigens by T helper cells

decreased T cell number ( J:6087 )

• of CD5+ T cells

increased macrophage cell number ( J:150402 )

• although heterozygotes and homozygotes have the same total number of peritoneal cells, the percentage expressing Mac-1 is an average of 30% in homozygotes versus an average of 14% in heterozygotes

cellular

decreased T cell proliferation ( J:6375 )

• to alloantigens by T helper cells