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Phenotypes Associated with This Genotype
Genotype
MGI:3698307
Allelic
Composition		 Lcktm1Dbs/Lcktm1Dbs
Tg(TcraTcrb)1100Mjb/0
Genetic
Background		 involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lcktm1Dbs mutation (0 available); any Lck mutation (96 available)
Tg(TcraTcrb)1100Mjb mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased T cell proliferation ( J:114660 )
• transgenic CD8+ thymocytes are not fully mature
abnormal positive T cell selection ( J:114660 )
• positive selection of CD4 and CD8 lineage is diminished

immune system
decreased T cell proliferation ( J:114660 )
• transgenic CD8+ thymocytes are not fully mature
abnormal positive T cell selection ( J:114660 )
• positive selection of CD4 and CD8 lineage is diminished

cellular
decreased T cell proliferation ( J:114660 )
• transgenic CD8+ thymocytes are not fully mature

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory