Phenotypes Associated with This Genotype

Genotype
MGI:3698156

• Allelic Composition: Cd3g^tm1Amk/Cd3g^tm1Amk; Tg(Igh-Pim1)1Brn/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6LiA * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased thymocyte number ( J:114561 )

• thymocyte number is only about 1-2 x 10⁶ cells at 4-5 weeks of age compared to 200-300 x 10⁶ cells in wild-type mice

• presence of the transgene does not increase thymocyte number unlike in Rag2 null mice

hematopoietic system

decreased thymocyte number ( J:114561 )

• thymocyte number is only about 1-2 x 10⁶ cells at 4-5 weeks of age compared to 200-300 x 10⁶ cells in wild-type mice

• presence of the transgene does not increase thymocyte number unlike in Rag2 null mice

endocrine/exocrine glands

decreased thymocyte number ( J:114561 )

• thymocyte number is only about 1-2 x 10⁶ cells at 4-5 weeks of age compared to 200-300 x 10⁶ cells in wild-type mice

• presence of the transgene does not increase thymocyte number unlike in Rag2 null mice