Phenotypes Associated with This Genotype

Genotype
MGI:3698155

• Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa; Tg(Igh-Pim1)1Brn/0
• Genetic Background: involves: 129S/SvEv * C57BL/6LiA * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased thymocyte number ( J:114561 )

• thymocyte number is only about 5-15 x 10⁶ cells at 4-5 weeks of age compared to 200-300 x 10⁶ cells in wild-type mice

• however, a gradual increase in the number of thymocytes occurs with cell numbers similar to wild-type by 8-9 weeks of age

hematopoietic system

decreased thymocyte number ( J:114561 )

• thymocyte number is only about 5-15 x 10⁶ cells at 4-5 weeks of age compared to 200-300 x 10⁶ cells in wild-type mice

• however, a gradual increase in the number of thymocytes occurs with cell numbers similar to wild-type by 8-9 weeks of age

endocrine/exocrine glands

decreased thymocyte number ( J:114561 )

• thymocyte number is only about 5-15 x 10⁶ cells at 4-5 weeks of age compared to 200-300 x 10⁶ cells in wild-type mice

• however, a gradual increase in the number of thymocytes occurs with cell numbers similar to wild-type by 8-9 weeks of age