Phenotypes Associated with This Genotype

Genotype
MGI:3697908

• Allelic Composition: Sox13^tm1Jskg/Sox13^tm1Jskg
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

abnormal postnatal growth/weight/body size ( J:117301 )

• homozygotes display developmental abnormalities

postnatal growth retardation ( J:117301 )

• at 3 weeks of age, mutants are many-fold smaller than littermate controls

hematopoietic system

increased T cell proliferation ( J:117301 )

• gamma-delta and triple negative thymocytes show enhanced proliferation in mutants

decreased gamma-delta T cell number ( J:117301 )

• at E18.5, a decrease in number and proportion of gamma-deltal TCR+ (T cell receptor) cells is observed compared to littermate controls and heterozygotes

immune system

increased T cell proliferation ( J:117301 )

• gamma-delta and triple negative thymocytes show enhanced proliferation in mutants

decreased gamma-delta T cell number ( J:117301 )

• at E18.5, a decrease in number and proportion of gamma-deltal TCR+ (T cell receptor) cells is observed compared to littermate controls and heterozygotes

cellular

increased T cell proliferation ( J:117301 )

• gamma-delta and triple negative thymocytes show enhanced proliferation in mutants