Sox13^tm1Jskg
Targeted Allele Detail

Summary

• Symbol: Sox13^tm1Jskg
• Name: SRY (sex determining region Y)-box 13; targeted mutation 1, Joonsoo Kang
• MGI ID: MGI:3697320
• Synonyms: Sox13^-
• Gene: Sox13 Location: Chr1:133310041-133352115 bp, - strand Genetic Position: Chr1, 57.91 cM
• Alliance: Sox13^tm1Jskg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117301
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A floxed neo was inserted into intron 3 and an additional loxP site was inserted into intron 11. A ~500 bp deletion was created in intron 5 for ES cell screening purposes. Transient cre expression resulted in the deletion of exons 4-11. Semi-quantitative RT-PCR confirmed lack of expression in mutant thymus. (J:117301)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox13 Mutation: 58 strains or lines available

References

• Original: J:117301 Melichar HJ, et al., Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13. Science. 2007 Jan 12;315(5809):230-3
• All: 4 reference(s)