Mouse Genome Informatics
hm
    Apba2tm1Tsuz/Apba2tm1Tsuz
C57BL/6-Apba2tm1Tsuz
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
N
• despite increased amyloid protein levels, learning and memory behaviors are normal (J:148481)
• no changes in anxiety related behaviors or general locomotive activity are detected (J:148481)
• mice lose significantly more weight than cohoused wild-type mice under competitive feeding regimen
• however, under noncompetitive conditions no differences in food consumption or body weight are detected
• mice bury significantly fewer marbles than wild-type mice in the marble burying test
• mice are subordinated under competitive feeding conditions
• mice exhibit significantly reduced digging behavior with the introduction of thick bedding materials
• mice displace significantly fewer food pellets from a tube in a burrowing test
• total number of resident social interactions with intruder mice are significantly decreased in a resident-intruder test

nervous system
N
• no defects in basal synaptic transmission, paired pulse facilitation or long-term potentiation are detected in contrast to expectations from known interactions of the protein with synaptic machinery involved in regulating neurotransmitter release (J:148481)

growth/size
• mice lose significantly more weight than cohoused wild-type mice under competitive feeding regimen
• however, under noncompetitive conditions no differences in food consumption or body weight are detected

homeostasis/metabolism
• significant attenuation of the hypothermal response induced by a selective 5-HT1A receptor agonist, 8-OH-DPAT
• significantly higher in the hypothalamus and somatosensory cortex

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Alzheimer Disease; AD 104300 J:148481