Phenotypes Associated with This Genotype

Genotype
MGI:3697817

• Allelic Composition: Apba2^tm1Tsuz/Apba2^tm1Tsuz
• Genetic Background: C57BL/6-Apba2^tm1Tsuz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:148481 )

N • despite increased amyloid protein levels, learning and memory behaviors are normal

N • no changes in anxiety related behaviors or general locomotive activity are detected

abnormal response to new environment ( J:148481 )

• mice exhibit significantly reduced digging behavior with the introduction of thick bedding materials

abnormal eating behavior ( J:148481 )

• mice lose significantly more weight than cohoused wild-type mice under competitive feeding regimen

• however, under noncompetitive conditions no differences in food consumption or body weight are detected

decreased aggression towards male mice ( J:148481 )

• mice are subordinated under competitive feeding conditions

decreased anxiety-related response ( J:148481 )

• mice bury significantly fewer marbles than wild-type mice in the marble burying test

abnormal response to novel object ( J:148481 )

• mice displace significantly fewer food pellets from a tube in a burrowing test

abnormal social investigation ( J:148481 )

• total number of resident social interactions with intruder mice are significantly decreased in a resident-intruder test

nervous system

nervous system phenotype ( J:148481 )

N • no defects in basal synaptic transmission, paired pulse facilitation or long-term potentiation are detected in contrast to expectations from known interactions of the protein with synaptic machinery involved in regulating neurotransmitter release

growth/size/body

decreased body weight ( J:148481 )

• mice lose significantly more weight than cohoused wild-type mice under competitive feeding regimen

• however, under noncompetitive conditions no differences in food consumption or body weight are detected

homeostasis/metabolism

abnormal body temperature homeostasis ( J:148481 )

• significant attenuation of the hypothermal response induced by a selective 5-HT1A receptor agonist, 8-OH-DPAT

increased serotonin level ( J:148481 )

• significantly higher serotonin levels in the hypothalamus and somatosensory cortex

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	Alzheimer's disease	DOID:10652		J:148481