Phenotypes for Acvr2a Acvr2b MGI:3697598 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Acvr2a^tm1Hsch/Acvr2a^tm1Hsch Acvr2b^tm1.1Spo/Acvr2b^tm1.1Spo
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr2a^tm1Hsch mutation (0 available); any Acvr2a mutation (39 available)
Acvr2b^tm1.1Spo mutation (0 available); any Acvr2b mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning ( J:114533 )

embryo

embryonic growth arrest ( J:114533 )

• development is arrested at the gastrulation stage (E8.5)

abnormal embryonic tissue morphology ( J:114533 )

• the embryonic tissues grow outside of the yolk sac

embryonic-extraembryonic boundary constriction ( J:114533 )

• exhibit constrictions at the junction between the extraembryonic and embryonic regions at E7.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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