About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3697518
Allelic
Composition		 Foxp3tm1Tch/Y
Stat6tm1Gru/Stat6tm1Gru
Genetic
Background		 C.129-Stat6tm1Gru Foxp3tm1Tch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm1Tch mutation (2 available); any Foxp3 mutation (55 available)
Stat6tm1Gru mutation (4 available); any Stat6 mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality at weaning, complete penetrance ( J:117165 )
• median survival is increased to 23 days; however the upper limit of survival span is not increased compared to Foxp3 single hemizygotes

immune system
immune system phenotype ( J:117165 )
N
• normalized levels of IgE
increased eosinophil cell number ( J:117165 )
• increased compared to wild-type but decreased compared to Foxp3 single hemizygotes
abnormal cytokine secretion ( J:117165 )
• profoundly impaired production of Th2 cytokines and enhanced production of Th1 cytokines

respiratory system
respiratory system phenotype ( J:117165 )
N
• goblet cell metaplasia in the lungs is absent

hematopoietic system
increased eosinophil cell number ( J:117165 )
• increased compared to wild-type but decreased compared to Foxp3 single hemizygotes

homeostasis/metabolism

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory