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Phenotypes Associated with This Genotype
Genotype
MGI:3697395
Allelic
Composition		 Casp8tm1Hed/Casp8tm1Hed
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp8tm1Hed mutation (1 available); any Casp8 mutation (45 available)
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B-1 B cell number ( J:116713 )
• modest reduction in B1 cells (~10%) in peritoneal cavity is seen
decreased marginal zone B cell number ( J:116713 )
• reduction in percentage of marginal zone B cells is observed
spleen hypoplasia ( J:116713 )
• spleen cell number is increased ~30% compared to wild-type
decreased B cell proliferation ( J:116713 )
• in response to LPS and dsRNA, B cells have decreased proliferative response
• cells stimulated through Tlr9 or antigen receptor show similar proliferation and apoptosis to wild-type cells
abnormal immunoglobulin level ( J:116713 )
• mice mount an inferior IgM response to LPS immunization

hematopoietic system
decreased B cell proliferation ( J:116713 )
• in response to LPS and dsRNA, B cells have decreased proliferative response
• cells stimulated through Tlr9 or antigen receptor show similar proliferation and apoptosis to wild-type cells
decreased B-1 B cell number ( J:116713 )
• modest reduction in B1 cells (~10%) in peritoneal cavity is seen
decreased marginal zone B cell number ( J:116713 )
• reduction in percentage of marginal zone B cells is observed
spleen hypoplasia ( J:116713 )
• spleen cell number is increased ~30% compared to wild-type
abnormal immunoglobulin level ( J:116713 )
• mice mount an inferior IgM response to LPS immunization

cellular
increased apoptosis ( J:116713 )
• cells treated with LPS or dsRNA show decreased survival (increased apoptosis) compared to controls at 24 hours, with decreased viability starting at 12 hours
• cells stimulated through Tlr9 or antigen receptor show similar proliferation and apoptosis to wild-type cells
decreased B cell proliferation ( J:116713 )
• in response to LPS and dsRNA, B cells have decreased proliferative response
• cells stimulated through Tlr9 or antigen receptor show similar proliferation and apoptosis to wild-type cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory