Phenotypes Associated with This Genotype

Genotype
MGI:3697307

• Allelic Composition: Tg(Defcr2-TAg)#Jig/0
• Genetic Background: FVB/N-Tg(Defcr2-TAg)#Jig

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal small intestine crypts of Lieberkuhn morphology ( J:43025 )

• 2- to 3-fold increase in the number of goblet cells in duodenal, jejunal, and ileal sections

• in distal jejunal sections the numbers of intermediate and granule goblet cells are increased

• however, mice do not develop intestinal tumors

decreased Paneth cell number ( J:43025 )

• 90 - 95% reduction in the number of Paneth cells at P28 and the area normally occupied by mature Paneth cells is partially filled with crypt base columnar cells as well as intermediate cells

endocrine/exocrine glands

abnormal small intestine crypts of Lieberkuhn morphology ( J:43025 )

• 2- to 3-fold increase in the number of goblet cells in duodenal, jejunal, and ileal sections

• in distal jejunal sections the numbers of intermediate and granule goblet cells are increased

• however, mice do not develop intestinal tumors

decreased Paneth cell number ( J:43025 )

• 90 - 95% reduction in the number of Paneth cells at P28 and the area normally occupied by mature Paneth cells is partially filled with crypt base columnar cells as well as intermediate cells