Tg(Defcr2-TAg)#Jig
Transgene Detail

Summary

• Symbol: Tg(Defcr2-TAg)#Jig
• Name: transgene insertion #, Jeffrey I Gordon
• MGI ID: MGI:2387572
• Synonyms: CR2-TAg, CR2-T-Ag, Tg(CR2-TAg)#Jig
• Transgene: Tg(Defcr2-TAg)#Jig Location: unknown
• Alliance: Tg(Defcr2-TAg)#Jig page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene contains the mouse Defcr2 (defensin related cryptdin 2) promoter region (-6500 to +34) and the wild-type allele of the SV40 large T antigen (Tag) gene. Expression of the transgene is targeted to neuro-endocrine cells of the prostate gland. The Defcr2 promoter was originally observed to drive expression in Paneth cells of intestinal crypts and subsequently in prostatic epithelium. Eight lines were established but the references do not distinguish between them. Data may have been pooled from more than one line. (J:43025, J:51704)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Defcr2-TAg)#Jig

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:43025 Garabedian EM, et al., Examining the role of Paneth cells in the small intestine by lineage ablation in transgenic mice. J Biol Chem. 1997 Sep 19;272(38):23729-40
• All: 7 reference(s)