Phenotypes Associated with This Genotype

Genotype
MGI:3696946

• Allelic Composition: Acvr2a^tm1Hsch/Acvr2a^tm1Hsch; Nodal^tm1Rob/Nodal⁺
• Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:57262 )

• embryonic lethality although time not specified

embryo

abnormal gastrulation ( J:57262 )

• over 60% show gastrulation defects

nervous system

decreased forebrain size ( J:57262 )

• 4 of 13 embryos that developed beyond gastrulation have a reduced forebrain

vision/eye

cyclopia ( J:57262 )

• 6 of 8 newborns display cyclopia

growth/size/body

abnormal head morphology ( J:57262 )

• 6 of 8 newborns show truncation of rostral head structures