Analysis Tools
reproductive system
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• mice treated with Gal1 exhibit less protection from stress-induced fetal loss compared to similarly treated wild-type mice
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immune system
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• in LPS-treated mice
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• in LPS-treated mice
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• 6 hours after LPS injection, TNF, Il12 and Ifng levels are substantially higher than in controls
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• after three subcutaneous injections of LPS into the flank, mice develop solid subcutaneous swellings whereas wild-type do not
• lesion is associated with infiltration of macrophages and neutrophils, edema, and extensive necrosis of dermal, epidermal, and muscle layers of skin
• 5 days after flank injection of CpG, mice develop solid subcutaneous swellings at the injection site; lesions show conspicuous edema, massive infiltration by macrophages and neutrophilic granulocytes, and extensive necrosis of the dermis, epidermis and muscle layer of the skin while lesions in controls do not display edema or necrosis and show infiltration by macrophages primarily
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• mice show exaggerated inflammatory response upon exposure to CML-mps-containing eluate compared to control
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• i.p. injection of LPS results in death in all animal by 48 hours, compared to survival of 23/25 controls
(J:117122)
• LPS-treated mice exhibit uncontrollable release of IL12 and TNF-alpha compared with wild-type mice
(J:118833)
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digestive/alimentary system
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• 7% of mutants develop rectal prolapse at 16 weeks of age
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• mice show exaggerated inflammatory response upon exposure to CML-mps-containing eluate compared to control
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homeostasis/metabolism
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• in LPS-treated mice
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• in LPS-treated mice
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