immune system
• mutant bone marrow is unable to reconstitute B cell development when transferred into lethally irradiated C57BL/6 mice
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• exhibit a decrease in immature and B cells in the bone marrow
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• pro-B cells exhibit impaired anti-Igbeta-induced NF-kappaB activation
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• block in early B cell development
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• impaired development of B cells results in severe B cell lymphopenia characterized by a decrease in B cell numbers in the spleen, lymph nodes, and peritoneal cavity to 1/60-1/100 of wild-type
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• exhibit a reduction in the fraction of viable B220+CD43-IgM- pre-B cells to 10% of wild-type
• 3-fold increase in frequency of apoptotic pre-B cells
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hematopoietic system
• mutant bone marrow is unable to reconstitute B cell development when transferred into lethally irradiated C57BL/6 mice
|
• exhibit a decrease in immature and B cells in the bone marrow
|
• pro-B cells exhibit impaired anti-Igbeta-induced NF-kappaB activation
|
• block in early B cell development
|
• impaired development of B cells results in severe B cell lymphopenia characterized by a decrease in B cell numbers in the spleen, lymph nodes, and peritoneal cavity to 1/60-1/100 of wild-type
|
• exhibit a reduction in the fraction of viable B220+CD43-IgM- pre-B cells to 10% of wild-type
• 3-fold increase in frequency of apoptotic pre-B cells
|