About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3696037
Allelic
Composition		 Jag2tm1Grid/Jag2tm1Grid
Lfngtm1Grid/Lfngtm1Grid
Genetic
Background		 involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jag2tm1Grid mutation (1 available); any Jag2 mutation (44 available)
Lfngtm1Grid mutation (1 available); any Lfng mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
decreased cochlear inner hair cell number ( J:62727 )
• surprisingly, at E18, double homozygotes display total suppression of the increase in number of hair cells in the IHC row observed in single Jag2tm1Grid homozygotes; this effect is specific for IHCs
abnormal cochlear outer hair cell morphology ( J:62727 )
• at E18, double homozygotes display disrupted patterning of the OHC rows, similar to single Jag2tm1Grid homozygotes
increased cochlear outer hair cell number ( J:62727 )
• at E18, double homozygotes display generation of supernumerary OHCs, similar to single Jag2tm1Grid homozygotes

nervous system
decreased cochlear inner hair cell number ( J:62727 )
• surprisingly, at E18, double homozygotes display total suppression of the increase in number of hair cells in the IHC row observed in single Jag2tm1Grid homozygotes; this effect is specific for IHCs
abnormal cochlear outer hair cell morphology ( J:62727 )
• at E18, double homozygotes display disrupted patterning of the OHC rows, similar to single Jag2tm1Grid homozygotes
increased cochlear outer hair cell number ( J:62727 )
• at E18, double homozygotes display generation of supernumerary OHCs, similar to single Jag2tm1Grid homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory