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Phenotypes Associated with This Genotype
Genotype
MGI:3695717
Allelic
Composition		 Apoetm1(APOE*2)Mae/Apoetm1(APOE*2)Mae
Ldlrtm1(LDLR)Mae/Ldlr+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1(APOE*2)Mae mutation (2 available); any Apoe mutation (163 available)
Ldlrtm1(LDLR)Mae mutation (2 available); any Ldlr mutation (79 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal lipid homeostasis ( J:67282 )
• exhibit increased clearance of non-HDL lipoproteins (VLDL and LDL) from plasma
decreased susceptibility to hyperlipidemia ( J:67282 )
• do not develop type III hyperlipoproteinemia, exhibiting normal plasma cholesterol and triglyceride levels on a normal chow diet
• more resistant to diet-induced hyperlipidemia than single Apoetm1(APOE)Mae homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory