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Phenotypes Associated with This Genotype
Genotype
MGI:3695389
Allelic
Composition
Lattm1.1Lov/Lattm1.1Lov
Lat2tm1Wz/Lat2tm1Wz
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lat2tm1Wz mutation (0 available); any Lat2 mutation (17 available)
Lattm1.1Lov mutation (0 available); any Lat mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• enlarged at 11 weeks of age
• spleen size is increased compared to Lat single homozygotes
• toal splenocyte number is (3.6 +/- 0.2) x 108 compared to (2.0 +/- 0.2) x 108 in Lat single homozygotes and (2.7 +/- 0.2) x 107 in wild-type mice
• about 68% of splenocytes are CD4+ cells
• enlarged at 11 weeks of age
• lymph node size is increased compared to Lat single homozygotes
• high titers of dsDNA antibodies are present at 6 weeks of age
• titers of dsDNA antibodies are higher and detected earlier than in Lat single homozygotes

hematopoietic system
• enlarged at 11 weeks of age
• spleen size is increased compared to Lat single homozygotes
• toal splenocyte number is (3.6 +/- 0.2) x 108 compared to (2.0 +/- 0.2) x 108 in Lat single homozygotes and (2.7 +/- 0.2) x 107 in wild-type mice
• about 68% of splenocytes are CD4+ cells

growth/size/body
• enlarged at 11 weeks of age
• spleen size is increased compared to Lat single homozygotes
• toal splenocyte number is (3.6 +/- 0.2) x 108 compared to (2.0 +/- 0.2) x 108 in Lat single homozygotes and (2.7 +/- 0.2) x 107 in wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory