immune system
• enlarged at 11 weeks of age
• spleen size is increased compared to Lat single homozygotes
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• toal splenocyte number is (3.6 +/- 0.2) x 108 compared to (2.0 +/- 0.2) x 108 in Lat single homozygotes and (2.7 +/- 0.2) x 107 in wild-type mice
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• about 68% of splenocytes are CD4+ cells
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• enlarged at 11 weeks of age
• lymph node size is increased compared to Lat single homozygotes
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• high titers of dsDNA antibodies are present at 6 weeks of age
• titers of dsDNA antibodies are higher and detected earlier than in Lat single homozygotes
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hematopoietic system
• enlarged at 11 weeks of age
• spleen size is increased compared to Lat single homozygotes
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• toal splenocyte number is (3.6 +/- 0.2) x 108 compared to (2.0 +/- 0.2) x 108 in Lat single homozygotes and (2.7 +/- 0.2) x 107 in wild-type mice
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• about 68% of splenocytes are CD4+ cells
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growth/size/body
• enlarged at 11 weeks of age
• spleen size is increased compared to Lat single homozygotes
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• toal splenocyte number is (3.6 +/- 0.2) x 108 compared to (2.0 +/- 0.2) x 108 in Lat single homozygotes and (2.7 +/- 0.2) x 107 in wild-type mice
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