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Phenotypes Associated with This Genotype
Genotype
MGI:3695303
Allelic
Composition		 Edn1tm1Ywa/Edn1tm1Ywa
Tg(AQP2-cre)2Dek/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edn1tm1Ywa mutation (1 available); any Edn1 mutation (24 available)
Tg(AQP2-cre)2Dek mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased systemic arterial systolic blood pressure ( J:116002 )
• mice have significantly elevated systolic blood pressure compared to controls as well as Ednra and Ednrb conditional knockout mice on a normal sodium diet
• on a high sodium diet, systolic blood pressure increases significantly compared to controls; change in BP between normal and high sodium diets is much greater than in Ednra or Ednrb conditional mutants

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory