Phenotypes Associated with This Genotype

Genotype
MGI:3695272

• Allelic Composition: Cdh1^tm1Jjon/Cdh1^tm1Jjon; Trp53^tm1Brn/Trp53⁺; Tg(KRT14-cre)8Brn/0
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

abnormal tumor vascularization ( J:116152 )

• mammary tumors show less vascularization, especially in periphery compared to double conditional null mice

increased mammary adenocarcinoma incidence ( J:116152 )

• mice show longer tumor latency periods (495 days) compared to double conditional knockouts (214 days)

• shift towards invasive from expansive carcinoma is observed with tumors classified as invasive lobulocarcinoma (ILC) developing multifocally in several mammary glands

• carcinosarcomas (having elements of carcinoma and sarcoma) develop, having spindle shaped cell morphology with large cells with pleomormphic nuclei; these display both expansive and invasive growth

• massive central necrosis is observed

increased skin tumor incidence ( J:116152 )

• mice show longer tumor latency periods (495 days) compared to double conditional knockouts (214 days)

• often show phenotypic change from expansive to invasive growth

• tumors may invade subcutaneous fat or carnous muscle in irregular strands and nest with polymorphic cell with dyskeratosis

increased metastatic potential ( J:116152 )

• in females presenting carcinomas ~1 cm in diameter, majority of tumors show extensive local invasion with ~50% demonstrating metastasis to draining and distant lymph nodes

• minority of animals show dissociated or loosely clustered lobulocarcinoma (ILC) cells in lungs, liver, gastrointestinal and urogenital tracts, and pancreas, or diffusely throughout peritoneal cavity

cardiovascular system

abnormal tumor vascularization ( J:116152 )

• mammary tumors show less vascularization, especially in periphery compared to double conditional null mice

integument

increased mammary adenocarcinoma incidence ( J:116152 )

• mice show longer tumor latency periods (495 days) compared to double conditional knockouts (214 days)

• shift towards invasive from expansive carcinoma is observed with tumors classified as invasive lobulocarcinoma (ILC) developing multifocally in several mammary glands

• carcinosarcomas (having elements of carcinoma and sarcoma) develop, having spindle shaped cell morphology with large cells with pleomormphic nuclei; these display both expansive and invasive growth

• massive central necrosis is observed

increased skin tumor incidence ( J:116152 )

• mice show longer tumor latency periods (495 days) compared to double conditional knockouts (214 days)

• often show phenotypic change from expansive to invasive growth

• tumors may invade subcutaneous fat or carnous muscle in irregular strands and nest with polymorphic cell with dyskeratosis

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:116152 )

• mice show longer tumor latency periods (495 days) compared to double conditional knockouts (214 days)

• shift towards invasive from expansive carcinoma is observed with tumors classified as invasive lobulocarcinoma (ILC) developing multifocally in several mammary glands

• carcinosarcomas (having elements of carcinoma and sarcoma) develop, having spindle shaped cell morphology with large cells with pleomormphic nuclei; these display both expansive and invasive growth

• massive central necrosis is observed