Phenotypes Associated with This Genotype

Genotype
MGI:3695270

• Allelic Composition: Trp53^tm1Brn/Trp53^tm1Brn; Tg(KRT14-cre)8Brn/0
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:126551 )

• mice develop mammary gland and skin tumors with a latency of 299 days

• mice develop mammary types of carcinoma (38%), biphasic carcinoma that is poorly defined (48%) and biphasic carcinoma that is well defined (14%)

increased mammary adenocarcinoma incidence ( J:116152 )

• mice develop mostly single mammary carcinomas and carcinosarcomas with a median latency of 330 days

• most tumors are intermediate grade adenocarcinomas or high-grade solid carcinomas characterized by expansive growth pattern with large epithelial cells forming solid nest or irregular glands

• some tumors have a carcinosarcoma phenotype (elements of carcinoma and sarcoma) involving epithelial and mesenchymal elements with a metaphasic and biphasic histology

increased skin tumor incidence ( J:116152 , J:126551 )

• small numbers of skin carcinomas develop with latency of 330 days develop (J:116152)

• may be classified as pilomatriculomas or squamous cell carcinomas, without metastasis (J:116152)

• mice develop mammary gland and skin tumors with a latency of 299 days (J:126551)

increased pilomatricoma incidence ( J:116152 )

increased squamous cell carcinoma incidence ( J:116152 )

• develop in ~25% of females

integument

increased mammary gland tumor incidence ( J:126551 )

• mice develop mammary gland and skin tumors with a latency of 299 days

• mice develop mammary types of carcinoma (38%), biphasic carcinoma that is poorly defined (48%) and biphasic carcinoma that is well defined (14%)

increased mammary adenocarcinoma incidence ( J:116152 )

• mice develop mostly single mammary carcinomas and carcinosarcomas with a median latency of 330 days

• most tumors are intermediate grade adenocarcinomas or high-grade solid carcinomas characterized by expansive growth pattern with large epithelial cells forming solid nest or irregular glands

• some tumors have a carcinosarcoma phenotype (elements of carcinoma and sarcoma) involving epithelial and mesenchymal elements with a metaphasic and biphasic histology

increased skin tumor incidence ( J:116152 , J:126551 )

• small numbers of skin carcinomas develop with latency of 330 days develop (J:116152)

• may be classified as pilomatriculomas or squamous cell carcinomas, without metastasis (J:116152)

• mice develop mammary gland and skin tumors with a latency of 299 days (J:126551)

increased pilomatricoma incidence ( J:116152 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:126551 )

• mice develop mammary gland and skin tumors with a latency of 299 days

• mice develop mammary types of carcinoma (38%), biphasic carcinoma that is poorly defined (48%) and biphasic carcinoma that is well defined (14%)

increased mammary adenocarcinoma incidence ( J:116152 )

• mice develop mostly single mammary carcinomas and carcinosarcomas with a median latency of 330 days

• most tumors are intermediate grade adenocarcinomas or high-grade solid carcinomas characterized by expansive growth pattern with large epithelial cells forming solid nest or irregular glands

• some tumors have a carcinosarcoma phenotype (elements of carcinoma and sarcoma) involving epithelial and mesenchymal elements with a metaphasic and biphasic histology