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Phenotypes Associated with This Genotype
Genotype
MGI:3695216
Allelic
Composition		 Ceacam1tm1Rsb/Ceacam1tm1Rsb
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ceacam1tm1Rsb mutation (0 available); any Ceacam1 mutation (40 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell proliferation ( J:116136 )
• anti-CD3 and anti-CD28 stimulation enhances proliferation compared to wild-type
abnormal cytokine secretion ( J:116136 )
• anti-CD3 and anti-CD28 stimulation enhances cytokine production by T cells
increased interferon-gamma secretion ( J:116136 )
• Ifng secretion by T cells upon anti-CD3 and anti-CD28 stimulation is enhanced
increased interleukin-2 secretion ( J:116136 )
• IL-2 secretion by T cells upon anti-CD3 and anti-CD28 stimulation is enhanced

hematopoietic system
increased T cell proliferation ( J:116136 )
• anti-CD3 and anti-CD28 stimulation enhances proliferation compared to wild-type

cellular
increased T cell proliferation ( J:116136 )
• anti-CD3 and anti-CD28 stimulation enhances proliferation compared to wild-type

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory